Validation of liver vessel segmentation and assessment/improvement of navigated laparoscopy with trackable laparoscopic instruments together with patient specific model-to-patient registration
This application is for a two-part pilot experiment for an EU project (High Performance Soft-tissue Navigation; 722068). The project involves validation and enrichment of a navigation system for laparoscopic surgery with additional features.
The research group is experienced with phantom, animal and human experiments.
The project includes:
¡q Liver vessel segmentation
¡q Liver and tumor segmentation
¡q Model-to-patient registration
¡q Pre-clinical and clinical evaluation and validation
Aim of this study:
¡q Validation of liver vessel segmentation
¡q To gather information about timing of contrast-enhanced CT/MR series in porcine, for the best possible image segmentation of liver and liver vessels
¡q Improve effectiveness and accuracy of liver and tumor segmentation algorithm
¡q Improve effectiveness and accuracy of model-to-patient registration algorithm
¡q Pre-clinical/Clinical evaluation and validation of new features in navigation system for laparoscopic surgery
Adverse effects on the animal: The animal will be in complete narcosis during imaging and laparoscopy. During CT/MR imaging, contrast will be given. The animal will undergo laparoscopy. After euthanasia, the animal will undergo open abdominal surgery so that liver vessels can be directly filled with contrasts for validation of segmentations.
Benefits: Increased precision and security of planning and treating patients with lesions in the liver.
Animals: Porcine (pig), 3 animals for each of the parts of the studies. Total of 6 animals.
3R:
¡q Replacement: Synthetic data, from retrospectively gathered images, and phantoms are used for initial development of algorithms until ex-vivo experiments cannot give significant results for further development and improvement. No ex-vivo experiment can be performed to differentiate vessels and validate its segmentation.
¡q Reduction: Several sub studies will be completed on one animal
¡q Refinement: Acute, one day, premedication and narcosis, euthanasia after about 8 hours
The research group is experienced with phantom, animal and human experiments.
The project includes:
¡q Liver vessel segmentation
¡q Liver and tumor segmentation
¡q Model-to-patient registration
¡q Pre-clinical and clinical evaluation and validation
Aim of this study:
¡q Validation of liver vessel segmentation
¡q To gather information about timing of contrast-enhanced CT/MR series in porcine, for the best possible image segmentation of liver and liver vessels
¡q Improve effectiveness and accuracy of liver and tumor segmentation algorithm
¡q Improve effectiveness and accuracy of model-to-patient registration algorithm
¡q Pre-clinical/Clinical evaluation and validation of new features in navigation system for laparoscopic surgery
Adverse effects on the animal: The animal will be in complete narcosis during imaging and laparoscopy. During CT/MR imaging, contrast will be given. The animal will undergo laparoscopy. After euthanasia, the animal will undergo open abdominal surgery so that liver vessels can be directly filled with contrasts for validation of segmentations.
Benefits: Increased precision and security of planning and treating patients with lesions in the liver.
Animals: Porcine (pig), 3 animals for each of the parts of the studies. Total of 6 animals.
3R:
¡q Replacement: Synthetic data, from retrospectively gathered images, and phantoms are used for initial development of algorithms until ex-vivo experiments cannot give significant results for further development and improvement. No ex-vivo experiment can be performed to differentiate vessels and validate its segmentation.
¡q Reduction: Several sub studies will be completed on one animal
¡q Refinement: Acute, one day, premedication and narcosis, euthanasia after about 8 hours