Breeding of TRAMP mice for treatment of prostate cancer and development of ultrasound imaging.

The TRAMP mice have been genetically modified to express the SV40T antigen under transcriptional control of the PB promotor, leading to specific expression in prostate epithelial cells. Consequently, the mice develop dysplastic lesions in the prostate, which progress to adenocarcinomas. Morphologically, the lesions resemble human prostate cancer. The model is therefore widely used for studies of progression of prostate cancer both on a molecular and a functional level. Furthermore, the onset of disease can be modified by dietary restriction or chemoprevention. The intention of this project is to continue breading of TRAMP model (continuation of FOTS 8092) for future treatment studies of prostate cancer investigating ultrasound enhanced treatments with conventional drugs. This application is primarily concerned with the breading, and ultrasound imaging development is a small part of it.