Exercised blood and Alzheimer's disease
FOTS 11740
At present, exercise training appears to be the most promising Alzheimer’s disease medicine. In this project we want to test the effect of exercise induced blood borne factors on cognitive function in a rat model of Alzheimer disease (Wistar - McGill-R-Thy1-APP). The rat model for Alzheimer´s disease will be characterized with respect to cognitive functions and other parameters. Some animals will be exercised on treadmill, which may cause moderate distress; otherwise all other procedures are non-invasive, or performed under anesthesia. Previously, we have performed neuronal cell culture experiments in order to determine the most optimal time point after exercise of which exercise induced blood borne factors are most beneficial for adaptations related to Alzheimer´s disease. This will enable us to adhere to demands for the 3Rs, as we will need fewer animals to test our hypothesis. Alzheimer´s disease is the most common form of dementia worldwide, and the prevalence is forecast to increase substantially in the coming years. To date, all treatment options are only marginally effective and preserve cognitive function only temporarily. The findings of this study will further explore the promising but not yet fully understood benefits exercise can have on this disease. More knowledge on this can be of major benefit, both for those affected by the disease and for the further scientific work in the field.
At present, exercise training appears to be the most promising Alzheimer’s disease medicine. In this project we want to test the effect of exercise induced blood borne factors on cognitive function in a rat model of Alzheimer disease (Wistar - McGill-R-Thy1-APP). The rat model for Alzheimer´s disease will be characterized with respect to cognitive functions and other parameters. Some animals will be exercised on treadmill, which may cause moderate distress; otherwise all other procedures are non-invasive, or performed under anesthesia. Previously, we have performed neuronal cell culture experiments in order to determine the most optimal time point after exercise of which exercise induced blood borne factors are most beneficial for adaptations related to Alzheimer´s disease. This will enable us to adhere to demands for the 3Rs, as we will need fewer animals to test our hypothesis. Alzheimer´s disease is the most common form of dementia worldwide, and the prevalence is forecast to increase substantially in the coming years. To date, all treatment options are only marginally effective and preserve cognitive function only temporarily. The findings of this study will further explore the promising but not yet fully understood benefits exercise can have on this disease. More knowledge on this can be of major benefit, both for those affected by the disease and for the further scientific work in the field.