Intracellular delivery of multifunctional micro- and nanocapsules with mesenchymal stem cells in murine model.

The problem addressed by this study is a complex of disadvantages of conventional drug formulations such as lack of targeting, drug degradation, suboptimal distribution, lack of concentration stability and sub noptimal biocompatibility. The introduction of multilayer polyelectrolyte microcapsules as drug carriers is currently attracting significant attention due to their high capacity, low toxicity profile, and wide possibilities for functionalization. Despite all of the advantages, these microcapsules also lack targeting. This problem may be overcome by the implementation of a cell-based platform, where various types of cells can be used as carriers for microcapsules loaded with desirable molecules for clinical or research purposes.
The aim of the study is to create cellular drug delivery system based on internalization of multifunctional microcapsules by mesenchymal stem cells.
In this study, we would like to investigate the distribution pattern and dynamics of the 2-3 µm sized multilayer polyelectrolyte microcapsules, either administered alone or after internalization into mesenchymal stem cells in vitro followed by administration of cells into animals.